10^th International Tissue Repair and Regeneration Congress

Why we need to Stop Vaping before Surgery The health hazards of smoking have been recorded for decades, but the research on vaping the smoking of electronic cigarettes, is still in its infancy. It’s the nicotine in cigarettes, which leads to the habit of smoking and poor healing, anaesthesia risks and a host of other potential complications for a surgery patient.  Electronic cigarettes often are characterized as a safer alternative to traditional tobacco products but vaping liquid contains nicotine, which significantly increases the risk for complications related to surgery and anaesthesia. Nicotine tightens blood vessels and decreases healthy circulation of blood, which delays healing and can lead to poor scarring, infection and other dangerous complications. Nicotine starves healing tissues of critical blood supply: Nicotine acts as a vasoconstrictor; it shrinks the blood vessels and decreases healthy circulation of blood, which is very much essential for ti...

A low-cost injectable hydrogel that could help wounds heal faster Wound healing can be tough and challenging, especially when a patient has other health obstacles that seriously can delay the process. Often injectable hydrogels are applied to irregular shaped wounds, like diabetic ulcers to form a temporary matrix to keep the wound stable while cells undergoes repair and rejuvenation . The condition is that current hydrogels are not porous enough and do not allow neighboring cells to pass through toward the wound to help it repair. A specific solution was discovered to make hydrogels more porous which can help heal the wound faster.  The researchers made a macroporous hydrogel by combining readily available gelatin microgels. The hydrogels that are a few hundred microns in diameter with an inexpensive enzyme named microbial transglutaminase (mTG). Gelatin is a natural protein derived from collagen, a protein found in connective tissue in the body such as s...

Cardiac Regeneration strategies: Staying young at Heart The heart tissue of mammals has the limited capacity to regenerate after an injury such as a heart attack or cardiac injuries in part due to the inability to reactivate a cardiac muscle cell and proliferation. Generally injured hearts do not heal themselves. Cardiac muscle cells or cardiomyocytes do not proliferate as much as necessary to replace dead tissue with new, pumping cells. Therefore, most people who had a severe heart attack or other injury related to the heart, will develop heart failure and that’s the leading reason of mortality from Heart Diseases. As we know that cell proliferation is much essential for the tissue regeneration and cardiomyocytes are highly specialized cells which involves in maintaining the pumping of heart. In previous findings it has been proved that the Hippo pathway stops the Proliferation of cardiomyocytes by inhibiting the activity of YAP pathway. For the reason, a mouse model was de...

Mesenchymal Stem Cells plays a vital role in  Wound Repair It has been scientifically proven that stem cells play a crucial role in tissue renewal and regeneration. Mesenchymal stem cells (MSCs) are those parts of the most important population of adult stem cells which helps in Repair and Regeneration of tissue. MSCs have been isolated from various sites like connective tissues, such as adipose tissue, muscle, placenta, umbilical cord matrix, blood, liver, and dental pulp. Bone marrow. MSCs also act as a therapeutic agent for regenerative medicine, immune disorders, cancer, and gene therapy. Mesenchymal stems cells (MSCs) are frequently found in bone marrow and they play a vital role in repair of damaged organs. The transformation of a single MSC into complex tissue like bone and cartilage, then starts with its association with other MSCs in order to form microscopic clusters via a process called as condensation. Wound healing requires a coordinated interaction...