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Mesenchymal Stem Cells plays a vital role in
 Wound Repair

It has been scientifically proven that stem cells play a crucial role in tissue renewal and regeneration. Mesenchymal stem cells (MSCs) are those parts of the most important population of adult stem cells which helps in Repair and Regeneration of tissue. MSCs have been isolated from various sites like connective tissues, such as adipose tissue, muscle, placenta, umbilical cord matrix, blood, liver, and dental pulp. Bone marrow. MSCs also act as a therapeutic agent for regenerative medicine, immune disorders, cancer, and gene therapy.
Mesenchymal stems cells (MSCs) are frequently found in bone marrow and they play a vital role in repair of damaged organs. The transformation of a single MSC into complex tissue like bone and cartilage, then starts with its association with other MSCs in order to form microscopic clusters via a process called as condensation.


Wound healing requires a coordinated interaction between cells, growth factors, and extracellular proteins. In this process the endogenous mesenchymal stem cell (MSC), this coordinates the repair response by recruiting other host cells and secreting growth factors and matrix proteins. MSCs are self-renewing multipotent stem cells that can differentiate into various lineages of mesenchymal origin such as bone, fat, cartilage and tendon. In addition to multilineage differentiation capacity, MSCs regulate the immune response and then possess powerful tissue protective and reparative mechanisms by making these cells attractive for treatment of different diseases. 


The beneficial effect of the exogenous MSCs on wound healing was observed in a variety of animal models and in reported clinical cases. Specifically, they have been successfully used to treat chronic wounds and stimulate healing processes. Recent studies revealed that human placental membranes are the rich source of MSCs for tissue regeneration and repair. This review provides a brief summary of current knowledge of functional properties of MSCs and describes the use of MSCs for wound healing. Characterization of MSCs containing skin substitutes, demonstrating the presence of cytokines and key growth factors uniquely suited to aid in wound repair and Regeneration.
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